FORM 2
THE PATENT ACT, 1970
(39 of 1970)
&
THE PATENT RULES, 2003
COMPLETE SPECIFICATION
(See section 10 and rule 13)
1. TITLE OF THE INVENTION: Neodymium Magnet for Transcranial Magnetic Stimulation by Permanent Magnet Therapy (TMS-PM)
2. APPLICANT
(a) Name: Dr Sagar Arvind Jawale
(b) Nationality: INDIAN
(c) Address: C/o Dr. Sagar Jawale, Jawale hospital, Near SBI, Jilha Peth, Gandhi
Nagar, Jalgaon-425001
Phone: +91-9370000380
Email address: drsagarjawale@gmail.com
Type of patent application: Complete specification
Preamble to the description: The following specification describes the invention. I describe a Neodymium magnet with high power knob to hold by a finger for Transcranial Magnetic Stimulation by Permanent Magnet Therapy (TMS-PM).
Field of invention: The invention is in pediatric medicine, adult medicine in the faculty of paediatric and adult neurology.
Background: Transcranial magnetic stimulation (TMS) [1,2] of the brain, also known as repetitive transcranial magnetic stimulation (r TMS), is a non-invasive form of brain stimulation in which a changing magnetic field is used to cause electric current at a specific area of the brain through electromagnetic induction. An electric pulse generator, or stimulator, is connected to a magnetic coil, which in turn is connected to the scalp. The stimulator generates a changing electric current within the coil which induces a magnetic field; this field then causes a second inductance of inverted electric charge within the brain itself. The frequency used in TMS is 5-10 Hz.
The FDA permitted marketing of TMS [2,4] as a treatment for major depression in 2008 and expanded the use to include TMS for treating pain associated with certain migraine headaches in 2013. The treatment is now tried on variety of neurological conditions such as Cerebral Palsy, Stroke, Mental retardation, depression and migraines.
I did my own research and found out a new therapy called Transcranial Magnetic Stimulation by Permanent Magnet Therapy (TMS-PM). It is reported for the first time in medical literature. The therapy needs a neodymium magnet. A neodymium magnet (also known as Nd Fe B, NIB or Neo magnet) is the most widely used type of rare-earth magnet. It is a permanent magnet made from an alloy of neodymium, iron, and boron to form the Nd2Fe14B tetragonal crystalline structure. Developed independently in 1984 by General Motors and Sumitomo Special Metals, neodymium magnets are the strongest type of permanent magnet available commercially. The magnetism of these magnets is long lasting up to 400 years. The human skull is a bad conductor of magnetic force; hence a strong magnetic flux is necessary to cross the resistance offered by skull bone. The conventional device produces about 5 Tesla magnetic power. The magnet was placed outside of human skull obtained from Human Anatomy department and from inside the skull the magnetic flux was recorded. It was found to be 2 Tesla in power which is sufficient to stimulate the brain. The magnet was moved rapidly by TO and FRO movements and the magnetometer inside skull recorded a strong oscillating magnetic field just created in conventional TMS device in the market. I did another experiment to prove my theory. An electrical coil of copper is taken and both ends connected to the multi-meter to measure AC voltage. Now, the magnet was placed over the copper coil and no electrical impulses were generated. Now I started a TO and FRO movement of the magnet over the coil and significant electrical impulses were generated in the multi meter. The brain tissue is just like the copper coil. If the permanent magnet is placed just over brain, no impulses of electricity are produced. When the magnet is made to move rapidly, then electrical impulses are created inside the brain, leading to brain stimulation. [3] Electrical brain stimulation produces Nerve Growth Factor (NGF) and Brain-derived neurotrophic factor (BDNF). Both the factors have variety of benefits for the repair of brain tissue.
Object of invention: The principal object of the invention is to have a portable, handy and cheap device for transcranial magnetic stimulation of brain and spinal cord. The machine for transcranial magnetic stimulation (TMS) is extremely costly in the range of Rs.50,00,000. The patient has to be brought to the hospital frequently for sessions and per session cost is Rs. 30,000. 30-50 sessions are necessary to have a clinical result. TMS requires an oscillating magnetic field which can only be produced by a huge and costly electromagnet
Summary: I describe a Neodymium magnet as a device for Transcranial Magnetic Stimulation by Permanent Magnet Therapy (TMS-PM). It is a Neodymium magnet of high power . The magnetic device is used for brain stimulation in variety of neurological conditions such as Cerebral Palsy, Stroke, Mental retardation, abnormalities of speech, depression and migraines. The magnetic device is used for spinal cord stimulation in variety of neurological conditions such as Cerebral Palsy, Spinal cord injury, Impotence, Transverse myelitis, multiple sclerosis, etc. The Transcranial Magnetic Stimulation by Permanent Magnet Therapy (TMS-PM) and its device magnet are reported for the first time in medical literature. The Neodymium magnet for TMS-PM is commercialized for a reasonable cost of Rs.10,000.
Detailed description: Complete specifications for Neodymium magnet as a device for Transcranial Magnetic Stimulation by Permanent Magnet Therapy (TMS-PM) are as follows:
The magnet used for TMS-PM is a Neodymium magnet of high magnetic power and a knob is fixed to the main body. Two fingers hold the device so that it does not fall during therapy.
The procedure of applying the magnet on brain and spinal cord is as follows. The therapist holds the magnet in hand by 2 fingers around the knob. A drop of lubricating KY jelly is applied to the magnet for its smooth movement over body. The magnet is moved in a TO and FRO massaging movement over the part of the brain and spinal cord to be stimulated. Alternately, a circular clock wise and anti- clock wise movement can also be done for the brain stimulation.
Application: The magnetic device is used for brain stimulation in variety of neurological conditions such as Cerebral Palsy, Stroke, Mental retardation, abnormalities of speech, depression and migraines. The magnetic device is used for spinal cord stimulation in variety of neurological conditions such as Cerebral Palsy, Spinal cord injury, Impotence, Transverse myelitis, multiple sclerosis, etc. The Transcranial Magnetic Stimulation by Permanent Magnet Therapy (TMS-PM) and its device magnet are reported for the first time in medical literature. The Neodymium magnet for TMS-PM is commercialized for a reasonable cost of Rs.10,000.
References:
1) Publication trends in transcranial magnetic stimulation: a 30-year panorama.
Lawson McLean A1.
Brain Stimul. 2019 May – Jun;12(3):619-627. doi: 10.1016/j.brs.2019.01.002. Epub 2019 Jan 9.
2) Fundamentals of Transcranial Electric and Magnetic Stimulation Dose: Definition, Selection, and Reporting Practices
Angel V. Peterchev,1,2 Timothy A. Wagner,3,4 Pedro C. Miranda,5 Michael A. Nitsche,6 Walter Paulus,6 Sarah H. Lisanby,1,7 Alvaro Pascual-Leone,8 and Marom Bikson9 Brain Stimulation. Author manuscript; available in PMC 2013 Oct 1.
Published in final edited form as: Brain Stimul. 2012 Oct; 5(4): 435–453. Published online 2011 Nov 1. doi: 10.1016/j.brs.2011.10.001. PMCID: PMC3346863. NIHMSID: NIHMS331673. PMID: 22305345
3) Transcranial Brain Stimulation with Rapidly Spinning High-Field Permanent Magnets
SANTOSH A. HELEKAR1,2 AND HENNING U. VOSS3, (Member, IEEE)
Received April 1, 2016, accepted May 6, 2016, date of publication May 19, 2016, date of current version June 13, 2016.
Digital Object Identifier 10.1109/ACCESS.2016.2568739
1Speech and Language Center, Department of Neurology, Houston Methodist Research Institute, Houston, TX 77030, USA. 2Department of Neurology and Neuroscience, Weill Cornell Medicine, New York, NY 10065, USA. 3Department of Radiology, Weill Cornell Medicine, New York, NY 10065, USA
4) Transcranial static magnetic field stimulation in man: making things as simple as possible?
Robert Koch Straße 40, 37075 Göttingen, Germany, Department of Clinical Neurophysiology, University Hospital Göttingen
J Physiol. 2011 Dec 15; 589(Pt 24): 5917–5918. doi: 10.1113/jphysiol.2011.221655. PMCID: PMC3286670
PMID: 22025669
The technical advances of my invention over the prior arts are as follows:
The prior arts devices for Transcranial Magnetic Stimulation (TMS) are extremely It is a bulky and heavy machine and can never be given to the patients for use at home. They are extremely costly with a cost ranging from Rs. 50 Lakh to 1 crore. The cost per session is about Rs.30,000 per session. 30-50 sessions are necessary to have a clinical result. Neurological patients are not ambulatory and carrying them to hospital for every session is difficult. Whereas, my invention is a Neodymium magnet with high power for Transcranial Magnetic Stimulation by Permanent Magnet Therapy (TMS-PM). The cost of the device is only Rs. 10,000 one time and cost per session is zero. Patients can take the therapy at home by massaging the device on desired part of the brain. It is a cheap alternative to TMS. It is portable in nature and can be given to the patient for treatment at home, a technical advance over prior arts. The prior art devices are imported and costly, whereas my device is cheap and indigenized. My device is in tune with government of India’s Make in India policy. My device is unique in design and application and no such prior art is described in India and internationally. My device is unique and reported for the first time in the medical literature. Hence, a patent must be granted for my invention.
The best method of performing my invention is as follows:
The therapist holds the magnet in hand by putting two fingers around the knob so that it does not fall during therapy. A drop of lubricating KY jelly is applied to the magnet for its smooth movement over body. The magnet is moved in a TO and FRO massaging movement over the part of the brain and spinal cord to be stimulated. Alternately, a circular clock wise and anti- clock wise movement can also be done for the brain stimulation.
I Claim:
1) Neodymium Magnet for Transcranial Magnetic Stimulation by Permanent Magnet Therapy (TMS-PM) is characterized by a Neodymium magnet with a round knob for holding; used for Transcranial Magnetic Stimulation by Permanent Magnet Therapy (TMS-PM) which is used for transcranial magnetic stimulation (TMS) of brain and spinal cord.
2)The Magnet as claimed in claim 1 is characterized by a Neodymium magnet (Figure:1,2) of sufficient power and size used for TMS-PM;
It is cheap and portable in nature and can be given to the patient for treatment at home, a technical advance over prior arts.
3) The Magnet as claimed in claim 1 has a knob (Figure:1,3 and figure:2,3) fixed to the main body at the top to the magnet.
5)The Magnet as claimed in claim 1 has sufficient magnetic power to cross the skull bone and spinal canal bones to reach the brain and spinal cord for their stimulation.
Dr. Sagar A. Jawale
